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TANDEM BIS-ALDOL REACTION OF KETONES: A FACILE ONE-POT SYNTHESIS OF 1,3-DIOXANES IN AQUEOUS MEDIUM

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Citation:

POLSHETTIWAR, V. AND R. S. VARMA. TANDEM BIS-ALDOL REACTION OF KETONES: A FACILE ONE-POT SYNTHESIS OF 1,3-DIOXANES IN AQUEOUS MEDIUM. DOI: 10.1021/jo70133, C. Dale Poulter (ed.), JOURNAL OF ORGANIC CHEMISTRY. American Chemical Society, Washington, DC, 72(19):7420 -7422, (2007).

Impact/Purpose:

Journal Article

Description:

A novel tandem bis-aldol reaction of ketone with paraformaldehyde catalyzed by polystyrenesulfonic acid in aqueous medium delivers 1,3-dioxanes in high yield. This one pot, operationally simple microwave-assisted synthetic protocol proceeds efficiently in water in the absence of organic solvent, with excellent yield.

Record Details:

Record Type:DOCUMENT( JOURNAL/ PEER REVIEWED JOURNAL)
Product Published Date:09/14/2007
Record Last Revised:07/16/2008
OMB Category:Other
Record ID: 181706