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ATTEMPS TO ESTABLISH EXPERIMENTAL CYCLOSPORA CAYETANENSIS INFECTION IN LABORATORY ANIMALS
Citation:
Eberhard, M. L., Y. R. Ortega, D. E. Hanes, E. K. Nace, R. Q. Do, M. G. Robl, K. Y. Won, C. Gavidla, N. L. Sass, K. Mansfield, A. Gozalo, J. Griffiths, R. Gilman, C. R. Sterling, AND M. J. Arrowood. ATTEMPS TO ESTABLISH EXPERIMENTAL CYCLOSPORA CAYETANENSIS INFECTION IN LABORATORY ANIMALS. Journal of Parasitology 86(3):577-582, (2000).
Description:
Attemps were made to develop an animal model for Cyclospora cayetanensis to identify a practical laboratory host for studing human cyclosporiasis. Oocysts collected from stool of infected humans in the United States, Haiti, Guatemala, Peru, and Nepal were held in potassium dichromate solution to allow development of sporozoites. The following animal types were inoculated: 9 strains of mice, including adult and neonatal immunocompetent and immune-deficient inbred and outbred strains, rats, sandrats, chickens, ducks, rabbits, gerbils, hamsters, ferrets, pigs, dogs, owl monkeys, and cynomolgus monkeys. Most animals were inoculated by gavage, although some of the primates were fed oocysts on food items. The animals were examined for signs of infection, particularly diarrhea, and stool samples were examined for 4-6 wk after inoculation. None of the animals developed patent infections or signs of infections. We conclude that none of the animals tested are susceptible to infection with C. cayetanensis.