INTEGRATING INNOVATIVE BIOMARKERS OF ENVIRONMENTALLY INDUCED DISEASE FOR CHILDREN IN AGRICULTURAL COMMUNITIES
Impact/Purpose:
As described above, the purpose of this study is to develop an integrative tool for evaluating the importance of knowledge
of biomarkers of susceptibility and early response for establishing the exposure-effect-disease relationship in adults and
children in agricultural and non-agricultural communities. While there has been more than a decade of research on children in
agricultural communities, many unanswered questions remain for both children and adults regarding patterns of exposure and the
link between exposure and disease. This proposed study will build on our current study and could significantly advance our
understanding of individual susceptibility and early indicators of biological effect. Hypothesis to be tested:
1. Knowing the genotype/phenotype for key genes that metabolize organophosphate (OP)
pesticides (biomarkers of susceptibility) will allow for improved prediction of exposure response and will decrease
uncertainty factors for predicting at risk individuals in agricultural communities.
2. Knowing polymporphisms of oxidant responsive pathways will allow us to:
- Better evaluate the potential for genomic biomarkers of early response with OP metabolites of exposure.
- Better predict relationship of biomarkers of effect (AChE) to respond in dose-response manner to the OP exposures in adults and children.
- Better predict whether "omic" biomarkers of disease are correlated with OP exposure.
Description:
The proposed study is a supplement to our EPA/NIEHS funded Center for Child Environmental Health Risks Research (CHC). We propose to develop an integrative tool for evaluating the importance of knowledge of biomarkers of susceptibility and early response for establishing the exposure-effect-disease relationship in adults and children in agricultural and non-agricultural communities. This study will examine multiple levels of biomarkers including susceptibility, early biological effect, and biomarkers of effect.
Record Details:
Record Type:PROJECT(
ABSTRACT
)
Start Date:10/01/2005
Completion Date:09/30/2008
Record ID:
175996
Keywords:
GENOMIC BIOMARKERS, NEURODEGENERATIVE DISEASE,
Related Organizations:
Role
:OWNER
Organization Name
:UNIVERSITY OF WASHINGTON - SEATTLE
Citation
:Seattle
State
:WA
Zip Code
:98195
Project Information:
Approach
:We have the unique opportunity to coordinate this proposed study with an on-going community based participatory research child cohort study in the Yakima Valley (CBPR). This parent study is a part of the EPA/NIEHS funded Center for Child Environmental Health Risks Research (CHC). We will evaluate biomarkers of susceptibility (genotype for pesticide metabolism and oxidative protective pathways) and biomarkers of early biological effect (gene expression responses in oxidative response and cell death) and biomarkers of effect (cholinesterase and clinical disease pathways).
Cost
:$749,997.00
Research Component
:Biology/Life Sciences
Approach
:We have the unique opportunity to coordinate this proposed study with an on-going community based participatory research child cohort study in the Yakima Valley (CBPR). This parent study is a part of the EPA/NIEHS funded Center for Child Environmental Health Risks Research (CHC). We will evaluate biomarkers of susceptibility (genotype for pesticide metabolism and oxidative protective pathways) and biomarkers of early biological effect (gene expression responses in oxidative response and cell death) and biomarkers of effect (cholinesterase and clinical disease pathways).
Cost
:$749,997.00
Research Component
:Human Health
Approach
:We have the unique opportunity to coordinate this proposed study with an on-going community based participatory research child cohort study in the Yakima Valley (CBPR). This parent study is a part of the EPA/NIEHS funded Center for Child Environmental Health Risks Research (CHC). We will evaluate biomarkers of susceptibility (genotype for pesticide metabolism and oxidative protective pathways) and biomarkers of early biological effect (gene expression responses in oxidative response and cell death) and biomarkers of effect (cholinesterase and clinical disease pathways).
Cost
:$749,997.00
Research Component
:Health Effects
Approach
:We have the unique opportunity to coordinate this proposed study with an on-going community based participatory research child cohort study in the Yakima Valley (CBPR). This parent study is a part of the EPA/NIEHS funded Center for Child Environmental Health Risks Research (CHC). We will evaluate biomarkers of susceptibility (genotype for pesticide metabolism and oxidative protective pathways) and biomarkers of early biological effect (gene expression responses in oxidative response and cell death) and biomarkers of effect (cholinesterase and clinical disease pathways).
Cost
:$749,997.00
Research Component
:Children's Health
Project IDs:
ID Code
:R832733
Project type
:EPA Grant