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POLLUTION-ENHANCED ALLERGIC INFLAMMATION AND PHASE II ENZYMES
Impact/Purpose:
The objective of this research project is to study the role of Phase II enzymes in regulating responses to pollutants in: children’s upper airways; the lower airways of healthy and asthmatic individuals; and mechanistic animal and cellular models of allergic inflammation.
Description:
During Year 2, we intend to recruit adults and children for Aim #1, commence recruitment for Aim #2, and repeat our mouse/sulforaphane experiment in Nrf-2 knock-out mice to confirm that the action of sulforaphane is indeed through activation of Nrf-2.
Record Details:
Record Type:PROJECT( ABSTRACT )
Start Date:11/01/2003
Completion Date:10/31/2008
Record ID:
175790