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BIOAVAILABILITY AND BIOLOGICAL RESPONSE OF PBDES ADMINISTERED TO RATS IN HOUSEHOLD DUST
Citation:
RICHARDSON, V., H. HAKK, J. K. HUWE, J. J. DILIBERTO, H. M. STAPLETON, AND L. S. BIRNBAUM. BIOAVAILABILITY AND BIOLOGICAL RESPONSE OF PBDES ADMINISTERED TO RATS IN HOUSEHOLD DUST. Presented at Dioxin 2007, Tokyo, JAPAN, September 02 - 07, 2007.
Description:
Abstract Household dust has recently been implicated as a source of PBDE exposure. This study investigated the bioavailability of PBDEs in house dust administered through the diet as compared to PBDEs in oil via the diet. PBDEs in household dust were just as bioavailable as PBDEs dissolved in oil. Lower brominated congeners (tri-hexa) accounted for most of the PBDEs in adipose, brain, and carcass, whereas the higher congeners (hepta-deca) accounted for at least 50% of the PBDEs in liver. Hepatic Cyp2b mRNA expression increased at nearly equal amounts in both the high dose dust and oil exposed animals, demonstrating a biological response to dust. This suggests that components other than the PBDEs in the dust (ie. PAHs) are causing the Cyp1a1 induction.