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DIETARY ARSENIC EXPOSURE ASSESSMENT USING ENZYMATIC BASED EXTRACTION CONDITIONS AND DETECTION OF URINARY THIO-ARSENICALS AS METABOLITES OF EXPOSURE - MCEARD2
Citation:
CREED, JOHN T., P. A. CREED, J. ELLIS, S. CONKLIN, C. GALLAWA, A. YOUNG, C. A. SCHWEGEL, AND J. CARUSO. DIETARY ARSENIC EXPOSURE ASSESSMENT USING ENZYMATIC BASED EXTRACTION CONDITIONS AND DETECTION OF URINARY THIO-ARSENICALS AS METABOLITES OF EXPOSURE - MCEARD2. Presented at Central Regional Meeting of the American Chemical Society (CERMACS), Covington, KY, May 21, 2007.
Impact/Purpose:
The goal is to develop an extraction protocol that mimics the human digestive tract and then to use it to assess the bioavailable fraction of arsenic from complex dietary mixtures such as a daily composite -- to move current methods toward a better human physiologically-based exposure estimate method which approximates the "true" bioavailability of arsenic within an environmental or dietary matrix.
Description:
Inorganic arsenic is classified as a carcinogen and has been linked to lung and bladder cancer as well as other non-cancerous health effects. Because of these health effects the U.S. EPA has set a Maximum Contaminant Level (MCL) at 10ppb based on a linear extrapolation of risk and a Health Risk Reduction and Cost Analysis (HRRCA). A re-evaluation of the HRRCA will require the Agency to review scientific developments regarding arsenic's Mode of Action, treatment options and the aggregate exposure assessment. The scientific basis for any drinking water MCL is reviewed every six years.