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THE ROLE OF ANDROGENS AND ESTROGENS IN THE DEVELOPMENT OF BRAIN AND PERIPHERAL NERVOUS SYSTEM: APPROACHES TO DEVELOPING ANIMAL MODELS FOR SEXUALLY DIMORPHIC BEHAVIORS
Citation:
GRAY, L. E. THE ROLE OF ANDROGENS AND ESTROGENS IN THE DEVELOPMENT OF BRAIN AND PERIPHERAL NERVOUS SYSTEM: APPROACHES TO DEVELOPING ANIMAL MODELS FOR SEXUALLY DIMORPHIC BEHAVIORS. Presented at International Neurotoxicology Association, Asilomar, CA, June 15, 2007.
Impact/Purpose:
Presentation
Description:
This presentation provides an overview of research on the effects of hormonally active chemicals on sexual differentiation of the brain including (a) research on the role of androgens and estrogens in the development of the brain and peripheral nervous system, (b) approaches to differentiate activational and organization effects on sexually dimorphic behavior and (c) research on differences and similarities between human and rodent sexual differentiation of the brain. A rational framework for the study of the effects of chemicals on developmental of the sexually dimorphic nervous system will be discussed using examples of animal models used to study organizational effects of environmental estrogens, androgens, and antiandrogens on the central and peripheral nervous system. Approaches to experimental design and data analysis that can increase the utility of the research for regulatory decision-making will be discussed.
