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THE CELLULAR AND GENOMIC RESPONSE OF AN IMMORTALIZED MICROGLIA CELL LINE (BV2) TO CONCENTRATED AMBIENT PARTICULATE MATTER
Citation:
SAMA, P., THOMAS LONG, S. D. HESTER, J. Tajuba, J. Parker, L. C. CHEN, AND B. VERONESI. THE CELLULAR AND GENOMIC RESPONSE OF AN IMMORTALIZED MICROGLIA CELL LINE (BV2) TO CONCENTRATED AMBIENT PARTICULATE MATTER. INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, 19:1079-1087, (2007).
Impact/Purpose:
Our results show that the microglia respond with cellular evidence of oxidative stress and genomic evidence suggesting upregulation of innate immunity.
Description:
This manuscript describes cellular and genomic evidence that microglia exposed to concentrated air pollutants (CAPs). These were CAPs achieved from a previous study in which sub-chronically exposed transgenic animals develop neurodegeneration (Veronesi et al., Inhalation Tox, 2005). Since the microglia is a critical cell to neurodegeneration this study was warranted. Our results show that the microglia respond with cellular evidence of oxidative stress and genomic evidence suggesting upregulation of innate immunity. Therefore, a plausible link to neuroimmunological explanation for particulate matter and neurodegeneration is forwarded.
