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Citation:

Region 5 Study Consortium. NHEXAS PHASE I REGION 5 STUDY--STANDARD OPERATING PROCEDURE--HUMAN BIOLOGICAL MARKERS:BLOOD AND URINE SAMPLE COLLECTION AND ANALYSES (EOHSI-AP-209-040). U.S. Environmental Protection Agency, Washington, D.C.

Description:

This procedure describes the process for collecting and analyzing blood and urine samples. The presence of chemical contaminants in biological specimens such as blood, urine, and hair represent a measure of the internal dose or body burden for a given individual derived from the individual's environmental exposures. The occurrences of measurable levels in biological samples are, at the least, verification of exposure and uptake. A set of venous blood and urine samples was collected from each compliant participant in the Region NHEXAS Study. The blood samples were to be tested for lead, cadmium, and VOCs. The urine samples were to be tested for arsenic. Human blood and urine samples were analyzed by the Centers for Disease Control and Prevention/National Center for Environmental Health (CDC/NCEH) Division of Environmental Health Service in Atlanta, Georgia. This protocol describes the sample containers, sample collection, preservation, storage, shipping, and custody procedures. Detailed procedures are given in the Appendices for blood and urine sample collection, handling, storage, and shipment. Keywords: biomarkers; blood; urine; metals; VOCs.

The National Human Exposure Assessment Survey (NHEXAS) is a federal interagency research effort coordinated by the Environmental Protection Agency (EPA), Office of Research and Development (ORD). Phase I consists of demonstration/scoping studies using probability-based sampling designs. The Region 5 study was conducted in EPA's Region 5 (Ohio, Michigan, Illinois, Indiana, Wisconsin, and Minnesota), and included personal exposure, residential concentration, and biomarker measurements of metals and VOCs. The study was conducted by the Research Triangle Institute (RTI) and the Environmental and Occupational Health Sciences Institute (EOHSI). The scope and design of the study are detailed in the following article: E. Pellizzari et al., Population-Based Exposure Measurements in EPA Region 5: A Phase I Field Study in Support of the National Human Exposure Assessment Survey. Journal of Exposure Analysis and Environmental Epidemiology, Vol. 5, No. 3, 1995, pp. 327-358.

NOTE: The U.S. Environmental Protection Agency (EPA), through its Office of Research and Development (ORD), partially funded and collaborated in the research described here. Mention of trade names or commercial products does not constitute endorsement or recommendation by EPA for use. This SOP is part of the Quality Systems Implementation Plan (QSIP) that was reviewed by the EPA and approved for use in this demonstration/scoping study. This SOP was used in the study and is provided for documentation purposes. It does not reflect EPA methods and should not be construed as such. The methods were generated by the consortium to be used for the NHEXAS pilot study.

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