Impact/Purpose:

The aims of this project have not changed from the original application; original objectives for the report period have been met. However, specific collaborative case studies have been defined during the report period to facilitate testing and evaluating of the accomplishment of these aims.

Description:

• Incorporation of regulatory rules within the analysis of metabolic networks to restrict the alternative solutions and result in better estimation of internal fluxes that cannot be measured. This can be achieved utilizing logic-based programming.
• Investigation of different case studies involving toxic substances to determine and evaluate the alternative pathways involved in liver detoxification and analyze the dependence to central liver metabolism under different conditions.
• Extension of methodologies for evaluating significant pathways affected by DBP exposure and consistently evaluat ion of the level of cross-species conservation of important proteins.  Design study for obtaining relevant time-course expression data.

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