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CORRELATES BETWEEN HUMAN LUNG INJURY AFTER PARTICLE EXPOSURE AND RECURRENT AIRWAY OBSTRUCTION IN THE HORSE
Citation:
GHIO, A. J., M. R. MAZAN, A. M. HOFFMAN, AND N. E. ROBINSON. CORRELATES BETWEEN HUMAN LUNG INJURY AFTER PARTICLE EXPOSURE AND RECURRENT AIRWAY OBSTRUCTION IN THE HORSE. Equine Veterinary Journal. Equine Veterinary Journal Ltd., Fordham, Ely, Cambs, Uk, 38(4):362-367, (2006).
Impact/Purpose:
Extrapolating investigation of each field to the other species can further the understanding of particle-associated lung injury in both the human and the horse
Description:
Characteristics of the clinical presentation, physiologic changes, and pathology of the human response to particulate matter (PM) are comparable to inflammatory airway disease (lAD) and recurrent airway obstruction (RAO)lheaves in the horse. Both present with symptoms of cough, phlegm, wheezing, and shortness of breath. Physiologically, particle exposure in humans and lAD and RAO lheaves in horses can both be associated with acute and chronic decrements in pulmonary function and airway hyperreactivity. Blood tests can demonstrate changes in acute phase reactants and indices of coagulability. Finally, pathologic changes in human PM inhalational injury and lAD and RAO/heaves in the horse are comparable with an acute influx of neutrophils and chronic changes of emphysema and fibrosis. Rather than a form of either asthma or emphysema, lAD and RAOlheaves in the horse should be viewed as a model of particle-associated lung injury. Extrapolating investigation of each field to the other species can further the understanding of particle-associated lung injury in both the human and the horse.
