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IRIS Toxicological Review of Nitrobenzene (External Review Draft)
EPA announces the release of the Toxicological Review of Nitrobenzene and notice of the External Peer Review Panel Meeting in the March 29, 2007 Federal Register Notice. This draft assessment is provided for a 45-day public viewing and comment period. Public comments received on the Toxicological Review before April 30th will be provided to the external peer reviewers for their consideration. Any comments not received within the requested time period will be considered by EPA in the final report.
Citation:
U.S. EPA. IRIS Toxicological Review of Nitrobenzene (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-07/001.
Impact/Purpose:
This is an IRIS Tox Review External Review Draft
Description:
EPA has conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessments of nitrobenzene, that will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.
Nitrobenzene is used extensively in chemical manufacturing, especially in the synthesis of other industrial chemicals and intermediates. Most important among these is aniline. A re-assessment of the potential health effects of nitrobenzene has been undertaken. The draft assessment will present reference values for the noncancer effects (RfD and RfC) and a cancer assessment (IUR).
URLs/Downloads:
Toxicological Review of Nitrobenzene (External Review Draft) (PDF, 169 pp, 2133 KB, about PDF)APPENDIX B -1: DOSE-RESPONSE MODELING FOR DERIVATION OF AN RFD FOR NITROBENZENE (PDF, 62 pp, 417 KB, about PDF)
Charge to External Peer Reviewers (PDF, 4 pp, 32 KB, about PDF)
CONSOLIDATED COMMENTS FROM THE EXTERNAL PEER REVIEW (FINAL) (PDF, 43 pp, 228 KB, about PDF)
FR NOTICE: MARCH 29, 2007
