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A MULTI-RESIDUE METHOD FOR THE ANALYSIS OF INSECTICIDES COLLECTED ON COTTON SURFACE WIPES
Citation:
CLIFTON, M. AND D. M. STOUT. A MULTI-RESIDUE METHOD FOR THE ANALYSIS OF INSECTICIDES COLLECTED ON COTTON SURFACE WIPES. Presented at ASMS Conference on Mass Spectrometry, Indianapolis, IN, June 03 - 07, 2007.
Impact/Purpose:
The overall goal of this research program is to identify those chemicals, pathways, and activities that represent the highest potential exposures to children and to determine the factors that influence these exposures. The following objectives will address this goal: (1) Revise and refine the existing research plan for children's exposure measurements research. (2) Collect measurement data on children's exposures. (3) Provide analytical support to children's pesticide exposure research. (4) Develop analytical methods for pesticides in duplicate diet food samples. (5) Develop and apply analytical methods for other chemicals including but not limited to brominated diphenyl ethers, phthalates, perfluorinated chemicals. (6) Evaluate the impact of chiral chemistry on the risk to children and exposure assessment. (7) Provide support to the National Children's Study. (8) Perform data analyses to fill critical data gaps. (9) Conduct analyses of dietary samples and refine the dietary model for the dietary exposure algorithm.
Description:
A method was developed for the extraction, clean-up, and analysis of multiple pesticides from cotton wipe media used in human exposure studies to collect residues from residential hard surfaces. Measurements of pesticides are critical for estimating dermal and indirect ingestion exposure, particularly for children. Methods used previously for multi-residue analysis of cotton wipes have been difficult to use for routine analysis at trace levels due to extensive problems with matrix effects from the cotton media and the hard surfaces being sampled. This method incorporates a multi-stage SPE clean-up procedure to remove extraneous compounds. An effective approach to correct for extraction efficiency and matrix effects based primarily on response enhancement on the GC/MS system is described.