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DIESEL EXHAUST PARTICLE-INDUCED EPITHELIAL TOXICITY IS MODULATED BY UV-IRRADIATION -- NCSU
Citation:
MANZO, N., J. E. RICHARDS, R. SLADE, J. A. DYE, AND L. MARTIN. DIESEL EXHAUST PARTICLE-INDUCED EPITHELIAL TOXICITY IS MODULATED BY UV-IRRADIATION -- NCSU. Presented at NCSU College of Veterinary Medicine Research Forum, Raleigh, NC, March 09, 2007.
Description:
Asthma is a chronic inflammatory disorder of the airways affecting nearly 20 million individuals in the U.S alone. Asthmatic symptoms can be exacerbated by environmental insults like exposure to particulate matter (PM). Diesel exhaust particles (DEP) account for a portion of PM. Interactions of DEP with other atmospheric constituents, such as ultraviolet (UV) radiation, can chemically or physically transform its surface reactivity. The present study was conducted to determine how UV transformation of DEP affect normal airways cells, and possibly extending these findings to understand DEPs role in diseased airways.