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COMPARISON OF ACUTE NEUROBEHAVIORAL AND CHOLINESTERASE INHIBITORY EFFECTS OF N-METHYL CARBAMATES IN RAT
Citation:
MCDANIEL, KATHY L., S. J. PADILLA, R. S. MARSHALL, P. PHILLIPS, L. PODHORNIAK, Y. QIAN, AND V. C. MOSER. COMPARISON OF ACUTE NEUROBEHAVIORAL AND CHOLINESTERASE INHIBITORY EFFECTS OF N-METHYL CARBAMATES IN RAT. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 98(2):552-560, (2007).
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Description:
There are few studies evaluating direct functional and biochemical consequences of exposure. In the present study of the acute toxicity of seven N-methyl carbamate pesticides, we evaluated the dose-response profiles of cholinesterase (ChE) inhibition in brain and erythrocytes (RBCs), as well as motor activity (both horizontally and vertically directed) and clinical signs of overt toxicity. The chemicals tested were: carbaryl, carbofuran, formetanate, methiocarb, methomyl, oxamyl, and propoxur. In general, motor activity was a sensitive measure of ChE inhibition for all these carbamate pesticides, and vertical activity showed the greatest magnitude of effect at the highest doses compared to either horizontal activity or ChE inhibition. Brain and RBC ChE activities were generally affected similarly. Pearson correlation coefficients of within-subject data showed good correlation between the behavioral and biochemical endpoints, with brain ChE inhibition and horizontal activity showing the highest correlation values. Determination of benchmark dose (BMD) levels for 10% change in each endpoint also revealed that these two measures produced the lowest estimates. Thus, motor activity decreases are highly predictive of ChE inhibition for N-methyl carbamates, and vice versa.