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CHARACTERIZATION OF A CRYPTOSPORIDIUM MURIS INFECTION AND REINFECTION IN CF-1 MICE
Citation:
MILLER, T. A. CHARACTERIZATION OF A CRYPTOSPORIDIUM MURIS INFECTION AND REINFECTION IN CF-1 MICE. Veterinary Parasitology. Elsevier, Shannon, Ireland, 144(3-4):208-221, (2007).
Impact/Purpose:
1) Conduct laboratory evaluations of new methods for detection of protozoan parasites.
2) Determine the infective dose of parasitic protozoa to hosts given a variety of models that will assist in estimating the public health significance at various levels of occurrence.
The work in this task will support CCL2 and 3 and will be completed by 9/05.
Description:
To establish control values for circulating cells and immune associated organs over the course of a self-limiting Cryptosporidium muris infection and rechallenge infection, mice were evaluated at intervals starting before oral inoculation and ending after oocyst shedding had ceased. These values were used in other experiments to evaluate changes in these parameters induced by a single dose glucocorticoid immunosuppression model and in other immunosuppression studies.