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DSSTOX (DISTRIBUTED STRUCTURE-SEARCHABLE TOXICITY DATABASE NETWORK) PROJECT AND WEBSITE.
Citation:
RICHARD, A. M. AND M. WOLF. DSSTOX (DISTRIBUTED STRUCTURE-SEARCHABLE TOXICITY DATABASE NETWORK) PROJECT AND WEBSITE. Presented at Board of Scientific Counselors 2005, RTP, NC, June 19 - 20, 2006.
Impact/Purpose:
Major trends affecting public toxicity information resources have the potential to significantly alter the future of predictive toxicology. Chemical toxicity screening is undergoing shifts towards greater use of more fundamental information on gene/protein expression patterns and bioactivity and bioassay profiles, the latter generated with highthroughput screening technologies. Curated, systematically organized, and webaccessible toxicity and biological activity data in association with chemical structures, enabling the integration of diverse data information domains, will fuel the next frontier of advancement for QSAR (quantitative structure-activity relationship) and data mining technologies. The DSSTox project is supporting progress towards these goals on many fronts, promoting the use of formalized and structure-annotated toxicity data models, helping to interface these efforts with QSAR modelers, linking data from diverse sources, and creating a large, quality reviewed, central chemical structure information resource linked to various toxicity data sources
Description:
Distributed Structure-Searchable Toxicity Database Network