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MECHANISMS OF ACTION OF INHALED FIBERS, PARTICLES AND NANOPARTICLES IN LUNG AND CARDIOVASCULAR DISEASES
Citation:
MOSSMAN, B., P. BORN, V. CASTRANOVA, D. L. COSTA, K. DONALDSON, AND S. R. KLEEBERGER. MECHANISMS OF ACTION OF INHALED FIBERS, PARTICLES AND NANOPARTICLES IN LUNG AND CARDIOVASCULAR DISEASES. Particle and Fibre Toxicology. BioMed Central Ltd, London, Uk, 4:4, (2007).
Impact/Purpose:
to assemble a group of clinical and basic research scientists to present and discuss new data on the mechanistic effects of inhaled particulates on the onset and development of morbidity and mortality in the lung and cardiovascular system.
Description:
ABSTRACT: A symposium on the mechanisms of action of inhaled airborne particulate matter (PM),pathogenic particles and fibers such as silica and asbestos, and nanomaterials, defined as synthetic particles or fibers less than 100 nm in diameter, was held on October 27 and 28,
2005, at the Environmental Protection Agency (EPA)Conference Center in Research Triangle Park,North Carolina. The meeting was the eighth in a series of transatlantic
conferences first held in Penarth, Wales, at the Medical Research Council Pneumoconiosis Unit (1979), that have fostered long-standing collaborations between researchers in the fields of mineralogy, cell and molecular biology, pathology,toxicology, and environmental/occupational health. The goal of this meeting, which was largely supported by a conference grant from the NHLBI, was to assemble a group of clinical and basic research scientists to present and discuss new data on the mechanistic effects of inhaled particulates on the onset and development of morbidity and mortality in the lung and cardiovascular system. Another objective of the meeting was to discuss and
elucidate host susceptibility factors to adverse health effects associated with inhaled pathogenic particulates. A future goal is to use presented data in the design of strategies for prevention and treatment of particulate-associated morbidity and mortality, especially in susceptible populations. This synopsis encompasses information presented at platform presentations, although a number of outstanding and relevant poster presentations were
also featured at the meeting. We also reference recently published articles by investigators that were covered, in part or full, in their presentations.