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ENDOTHELIAL CELL DYSFUNCTION AND VASCULAR INFLAMMATION ARE ASSOCIATED WITH EXPOSURE TO FINE PARTICLES IN DIABETICS
Citation:
SCHNEIDER, A. I., M. HERBST, R. W. WILLIAMS, A. HINDERLITER, L. M. NEAS, F. HOLGUIN, A. PETERS, AND R. B. DEVLIN. ENDOTHELIAL CELL DYSFUNCTION AND VASCULAR INFLAMMATION ARE ASSOCIATED WITH EXPOSURE TO FINE PARTICLES IN DIABETICS. Presented at American Thoracic Society Meeting, San Francisco, CA, May 18 - 23, 2006.
Impact/Purpose:
research results
Description:
Exposure to fme airborne particulate matter (PM2.5) has been shown to be responsible for cardiovascular and hematological effects, especially in older people with cardiovascular disease. Some epidemiology studies suggest that diabetics may be a particularly susceptible population. The purpose ofthis study was to analyze the short-term effects of PM2.5 on inflammatory blood markers and on a marker ofendothelial function in diabetics. A prospective panel study was conducted on 22 people with diabetes in Chapel Hill, NC, from Nov 2005-Dec 2005. Each subject was studied for 4 consecutive days. Daily measurements ofPM2.5 and meteorological data were acquired on the rooftop of the patient exam site. Plasma levels ofinflammatory blood markers and brachial artery flow mediated dilatation (FMD) were also assessed on each day. Data were analyzed using random effects models adjusting for season, weekday and meteorology. Results are presented for an increase of l Oug/m' PM2.5 as percent changes ofmean with a 95% confidence interval. FMD decreased in association with PM2.5 during the fIrst 24 hours (¬20.5% [-37.4%; -3.6%]). Interleukin-6 (IL-6) showed a significant increase with a lag of 2 days (21.5% [7.0%; 36.0%D. Subjects with a BMI over 30 kg/nr' and subjects with glycosylated hemoglobin (HbAlc) over 7% showed higher IL-6 effects (24.5% [8.8%; 40.3%] and 25.6% [9.5%; 41.7%], respectively). These data demonstrate that PM exposure may cause immediate endothelial cell dysfunction while vascular inflammation may take up to two days to be apparent, and that heavier diabetics as well those with higher HbAI c levels may be especially responsive.