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Development of a Relative Potency Factor (RPF) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (Interagency Science Consultation Draft)
As per the May 21, 2009, IRIS process, all comments received from federal agencies and White House offices on draft IRIS assessments will be made publicly available. Accordingly, interagency comments and the interagency science consultation draft of the PAH Mixtures Approach and the charge to external peer reviewers are posted on this site.
Citation:
U.S. EPA. Development of a Relative Potency Factor (RPF) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (Interagency Science Consultation Draft) . U.S. Environmental Protection Agency, Washington, DC.
Impact/Purpose:
The purpose of the draft report is to provides a methodology for estimating cancer risk from exposure to PAH mixtures by summing doses of component PAHs after scaling the doses (with RPFs) relative to the potency of an index PAH (i.e., benzo[a]pyrene).
Description:
On February 26, 2010, the draft Development of a Relative Potency Factor (RPF) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures document and the charge to external peer reviewers were released for external peer review and public comment. The draft document and the charge to external peer reviewers were reviewed internally by EPA and by other federal agencies and White House Offices before public release. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments and the interagency science consultation draft of the PAH Mixtures Approach and the charge to external peer reviewers are posted on this site.
URLs/Downloads:
Development of a Relative Potency Factor (RPF) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (Draft September 2009) (PDF, 574 pp, 6918 KB, about PDF)Charge to Reviewers (Draft September 2009) (PDF, 4 pp, 57 KB, about PDF)
NASA comments on PAH Mixtures (PDF, 2 pp, 30 KB, about PDF)
NIOSH comments on PAH Mixtures (PDF, 1 pp, 9 KB, about PDF)
OMB comments on PAH Mixtures (PDF, 9 pp, 89 KB, about PDF)
DoD comments on PAH Mixtures (PDF, 14 pp, 112 KB, about PDF)
DoD comments on PAH Mixtures (Charge to Reviewers) (PDF, 2 pp, 23 KB, about PDF)