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COMMON ISSUES IN HUMAN AND ECOSYSTEM EXPOSURE ASSESSMENT: THE SIGNIFICANCE OF PARTITIONING, KINETICS, AND UPTAKE AT BIOLOGICAL EXCHANGE SURFACES
Citation:
MCKONE, T., W. J. RILEY, R. MADDALENA, R. ROSEBAUM, AND D. A. VALLERO. COMMON ISSUES IN HUMAN AND ECOSYSTEM EXPOSURE ASSESSMENT: THE SIGNIFICANCE OF PARTITIONING, KINETICS, AND UPTAKE AT BIOLOGICAL EXCHANGE SURFACES. Presented at ISEA/ISEE 2006, Paris, FRANCE, September 02 - 06, 2006.
Impact/Purpose:
1) Develop methods of ecological exposure (e.g. rapid , sensitive analytical screening methods for a select list of antibiotics widely used in agriculture primarily in CAFOs (confined animal feeding operations).
2) Do Measurements & Provide data for multicompartment models of fate and transport.
3) Study biomagnification of specific chemicals and toxic metals.
4) Study specific pharmaceuticals:
*Determine the routes of entry and the impact of environmental factors such as rainfall on the movement and survivorability of selected antimicrobials in the environment.
*Determine if the entry of agriculture based antibiotics into the environment contributes to resistance in bacterial populations.
*Determine the contribution from municipal waste water treatment plants to antibiotic loading in the environment.
5) Develop methods for the analysis of alkylphenol ethoxylates and derivatives.
Description:
Exogenous chemicals enter organisms through critical surfaces in the lung, gills, gut, and skin. Transfer across these boundaries is the first step in characterizing the ratio of tissue dose to external exposure. Surface processes and fugacity are important elements of both human and ecosystem exposure assessments.