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Ketoconazole in the Fathead Minnow Pimephales promelas: Reproductive Toxicity and Biological Compensation
Citation:
ANKLEY, G. T., K. M. JENSEN, M. D. KAHL, E. A. MAKYNEN, L. BLAKE, K. GREENE, R. D. JOHNSON, AND D. L. VILLENEUVE. Ketoconazole in the Fathead Minnow Pimephales promelas: Reproductive Toxicity and Biological Compensation. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 26(6):1214-1223, (2007).
Impact/Purpose:
To explain the reproductive effects of Ketoconazole, a pesticide which inhibits fungal growth
Description:
Ketoconazole (KTC) is a model pharmaceutical representing inidazole and triazole pesticides which inhibit fungal growth through blocking a cytochrome P450 (CYP)-mediated step in ergosterol biosynthesis. Overall, our data indicate that, while KTC adversely affects steroidogenesis and reproduction in the fathead minnow, the fish can compensate to some degree to mitigate some effects of the fungicide.