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NEUROSENSORY EFFECTS OF CHRONIC HUMAN EXPOSURE TO ARSENIC ASSOCIATED WITH BODY BURDEN AND ENVIRONMENTAL MEASURES
Citation:
OTTO, D. A., J. TELECH, J. S. MUMFORD, T. J. WADE, X. XIA, Y. LI, L. HE, AND K. WU. NEUROSENSORY EFFECTS OF CHRONIC HUMAN EXPOSURE TO ARSENIC ASSOCIATED WITH BODY BURDEN AND ENVIRONMENTAL MEASURES. HUMAN AND EXPERIMENTAL TOXICOLOGY. MacMillan Magazines LIMITED, London, Uk, 26(3):169-177, (2007).
Impact/Purpose:
to assess arsenic exposure and body burden
Description:
Exposure to arsenic in drinking water is known to produce a variety of health problems including peripheral neuropathy. Auditory, visual and somatosensory impairments have been reported in Mongolian farmers living in the Yellow River Valley where drinking water is contaminated by arsenic. In the present study, sensory tests including pinprick and vibration thresholds were administered to 320 residents with well-water arsenic levels ranging from non-detect to 690 ╡g/L. Vibration thresholds in the 2nd and 5th fingers of both hands were measured using a vibrothesiometer. Drinking water, urine and toenail samples were obtained to assess arsenic exposure and body burden. Regression analyses indicated significant associations of pinprick scores and vibration thresholds with all arsenic measures. Vibration thresholds were more strongly associated with urinary than water or nail arsenic measures, but odds ratios for decreased pinprick sensitivity were highest for the water arsenic measure. Results of the current study indicate neurosensory effects of arsenic exposure at concentrations well below the 1000 ╡g/L drinking water level specified by NRC and suggest that non-carcinogenic end-points such as vibration thresholds are useful in the risk assessment of exposure to arsenic in drinking water.
