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IRIS Toxicological Review and Summary Documents for 1,4-Dichlorobenzene (External Peer Review)
[12/20/06] The final report for the External Peer Review for the Toxicological Review and IRIS Summary for 1,4-Dichlorobenzene (Inhalation Cancer Assessment and RfC) was posted to the Web site.
Citation:
U.S. EPA. IRIS Toxicological Review and Summary Documents for 1,4-Dichlorobenzene (External Peer Review).
Impact/Purpose:
EPA's IRIS Program is announcing that an extension of the public comment period and rescheduling of the external peer review panel teleconference to review the draft document entitled, "Toxicological Review of Dichlorobenzene: In Support of Summary Information on the Integrated Risk Information System (IRIS)" (EPA/635/R-03/015), was published in the August 11, 2006 Federal Register [FDMS Docket ID: EPA-HQ-ORD-2004-0002].
Description:
The U.S. EPA has conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of 1,4-dichlorobenzene that will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.
[Update 10/12/06] The EPA extended the public comment period and rescheduled the external peer review panel meeting to review selected sections of the EPA National Center for Environmental Assessment (NCEA) final draft document titled, Toxicological Review of Dichlorobenzenes: In Support of Summary Information on the Integrated Risk Information System (IRIS)(EPA/635/R-03/015), regarding the inhalation reference concentration (RfC) and inhalation cancer assessment for 1,4-dichlorobenzene. EPA also changed the format of the external peer review meeting to include both a teleconference and an in-person panel meeting as described in the October 12, 2006 Federal Register Notice.
URLs/Downloads:
IRIS Toxicological Review of 1,4 - Dichlorobenzene (PDF, 234 pp, 2275 KB, about PDF)IRIS SUMMARY DOCUMENTS FOR 1,4 - DICHLOROBENZENE (PDF, 32 pp, 248 KB, about PDF)
Charge to External Reviewers for the IRIS Toxicological Review for 1,4 - Dichlorobenzene (PDF, 2 pp, 27 KB, about PDF)
CONSOLIDATED COMMENTS FROM THE EXTERNAL PEER REVIEW (FINAL) (PDF, 18 pp, 534 KB, about PDF)
FR NOTICE: OCTOBER 12, 2006
FR NOTICE: AUGUST 11, 2006
FR NOTICE: JULY 11, 2006
Full Paper: Toxicology to para - Dichlorobenzene (PDF, 11 pp, 2114 KB, about PDF)