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EVALUATION OF AN ENZYME-LINKED IMMUNOSORBENT ASSAY FOR BIOLOGICAL MONITORING OF 3-PHENOXYBENZOIC ACID IN URINE
Citation:
VAN EMON, J. M., J. C. CHUANG, J. FINEGOLD, R. M. TREJO, AND J. DURNFORD. EVALUATION OF AN ENZYME-LINKED IMMUNOSORBENT ASSAY FOR BIOLOGICAL MONITORING OF 3-PHENOXYBENZOIC ACID IN URINE. Presented at American Chemical Society National Meeting, San Francisco, CA, September 14, 2006.
Impact/Purpose:
The overall goal of this research program is to identify those chemicals, pathways, and activities that represent the highest potential exposures to children and to determine the factors that influence these exposures. The following objectives will address this goal:
Revise and refine the existing research plan for children's exposure measurements research.
Collect measurement data on children's exposures.
Provide analytical support to children's pesticide exposure research.
Develop analytical methods for pesticides in duplicate diet food samples.
Develop and apply analytical methods for other chemicals including but not limited to brominated diphenyl ethers, phthalates, perfluorinated chemicals.
Evaluate the impact of chiral chemistry on the risk to children and exposure assessment.
Provide support to the National Children's Study.
Perform data analyses to fill critical data gaps.
Conduct analyses of dietary samples and refine the dietary model for the dietary exposure algorithm.
Description:
Abstract describes the development of an enzyme-linked immunosorbent assay (ELISA) method for monitoring 2,4-dichlorophenoxyacetic acid (2,4-D exposures). The ELISA is compared with a gas chromatograhy/mass spectrometry procedure. ELISA method development steps and comparative results are given for spiked urine samples.