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EXPOSURE RELATED DOSE ESTIMATING MODEL ( ERDEM ) A PHYSIOLOGICALLY-BASED PHARMACOKINETIC AND PHARMACODYNAMIC ( PBPK/PD ) MODEL FOR ASSESSING HUMAN EXPOSURE AND RISK
Citation:
BLANCATO, J. N., F. W. POWER, R. N. BROWN, AND C. C. DARY. EXPOSURE RELATED DOSE ESTIMATING MODEL ( ERDEM ) A PHYSIOLOGICALLY-BASED PHARMACOKINETIC AND PHARMACODYNAMIC ( PBPK/PD ) MODEL FOR ASSESSING HUMAN EXPOSURE AND RISK. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-06/061 (NTIS PB2006-114712), 2006.
Impact/Purpose:
The overall goal of this task is to apply exposure and source apportionment tools (measurements and models) to support ongoing and planned health studies.
Description:
The Exposure Related Dose Estimating Model (ERDEM) is a PBPK/PD modeling system that was developed by EPA's National Exposure Research Laboratory (NERL). The ERDEM framework provides the flexibility either to use existing models and to build new PBPK and PBPK/PD models to address specific science questions. Over the past several years, ERDEM has been enhanced to improve ease of operation and to provide additional modeling capabilities. With these enhancements, ERDEM has been applied to a variety of chemicals as part of the regulatory risk assessment process. Applications for malathion and N- methyl carbamate were presented to and peer-reviewed by the FIFRA Scientific Advisory Panel.
URLs/Downloads:
NERLRTPHEASD_06084.PDF (PDF, NA pp, 22438 KB, about PDF)EXPOSURE RELATED DOSE ESTIMATING MODEL ( ERDEM ) A PHYSIOLOGICALLY-BASED PHARMACOKINETIC AND PHARMACODYNAMIC ( PBPK/PD ) MODEL FOR ASSESSING HUMAN EXPOSURE AND RISK