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'GREENER' SOLVENT-FREE CHEMICAL SYNTHESIS USING MICROWAVE IRRADIATION
Citation:
VARMA, R. S. 'GREENER' SOLVENT-FREE CHEMICAL SYNTHESIS USING MICROWAVE IRRADIATION. Presented at National Academy of Engineering (NAE) Northeastern Regional Meeting, University Park, PA, June 15 - 16, 2006.
Description:
Solvent-free approach that involves microwave (MW) irradiation of neat reactants (undiluted) catalyzed by the surfaces of less-expensive and recyclable mineral supports such as alumina, silica, clay, or 'doped' surfaces is presented which is applicable to a wide range of cleavage, condensation, cyclization, oxidation and reduction reactions including rapid one-pot assembly of heterocyclic compounds from in situ generated reactive intermediates. Synthesis of significant precursors and intermediates namely, enones, imines, enamines, nitroalkenes, and oxidized sulfur species is depicted and their value in concise synthesis of flavones, tetrahydroquinolones, 2-aroylbenzofurans, and thiazole derivatives is illustrated. The rationalization of microwave effects and mechanistic considerations possibly involving the intermediacy of polar transition states will be discussed.