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ENANTIOMER-SPECIFIC FATE AND EFFECTS OF MODERN CHIRAL PESTICIDES
Citation:
GARRISON, A. W. ENANTIOMER-SPECIFIC FATE AND EFFECTS OF MODERN CHIRAL PESTICIDES. Presented at Workshop on Chiral Xeniobiotics, Birmingham, UK, March 28, 2006.
Impact/Purpose:
To determine the environmental occurrences, fate, and effects of the enantiomers of selected chiral pesticides and other chiral pollutants.
Description:
This slide presentation presents enantiomer-specific fate and effects of modern chiral pesticides. The research areas presented were analytical separation of enantiomers; environmental occurrence of enantiomers; transformation rates and enantioselectivity; bioaccumulation; and enantioselectivity effects. Conclusions of the presentation were many modern pesticides are chiral; capillary electrophoresis is useful for laboratory studies of pesticide transformation; microbial transformation is usually observed to be enantioselective, but it is not possible at this time to predict the direction or extent of selectivity in a different environment; and enantiomers usually differ in their effects, including toxicity and ED activity, but little definitive work has been done with pesticides; metabonomics, proteomics and other modern molecular biochemistry techniques are applicable to investigate toxicity mechanisms; accurate risk assessment requires investigation of the fate and effects of each enantiomer of a chiral pesticide; and the ultimate goal of this research is to show whether the manufacture and use of single-enantiomer pesticides is of benefit to the environment.