You are here:
Perfluorooctanoic Acid (Pfoa) and Perfluorononanoic Acid (Pfna) in Neonatal Mice Following in Utero Exposure to 8-2 Fluorotelomer Alcohol (Ftoh)
Citation:
HENDERSON, W. M. Perfluorooctanoic Acid (Pfoa) and Perfluorononanoic Acid (Pfna) in Neonatal Mice Following in Utero Exposure to 8-2 Fluorotelomer Alcohol (Ftoh). Presented at Teratology Society 46th Annual Meeting, Tucson, AZ, June 24 - 29, 2006.
Impact/Purpose:
The general goals of this research are to meet OPPT's need for data and information regarding the stability of TBPPs in soils. We plan to address these needs with a series of lab experiments in which FBPs are exposed to selected natural and amended soils. We anticipate that, as we learn about the general behavior of FBPs in soils, we will develop a protocol for testing FBPs in soils that has procedures similar to the guidelines described in OECD 307.
Description:
The fluorotelomer alcohols (FTOHs) are the probable precursors of a homologous series of perfluoroalkyl carboxylic acids (PFCAs) detected globally in both mammalian and environmental samples. Recently, 8-2 FTOH has been classified as a xenoestrogen and its derivatives, perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA), have been correlated with developmental toxicity in rats and rabbits. Previous work in our laboratory determined that in mice, fetal concentrations of the terminal metabolites, PFOA and PFNA, increase up to gestation day (GD) 18 following a single oral maternal exposure on GD8. However, maternal serum and liver concentrations gradually decreased having reached peak concentrations by 24 h post-treatment. The purpose of this study was to investigate the neonatal transfer of these stable metabolites following in utero exposure to 8-2 FTOH. In conclusion, exposure of neonates to metabolites of 8-2 FTOH can occur both pre- and postnatally following a single oral maternal dose on GD8.