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QUANTITATIVE MORPHOLOGY
Citation:
JENSEN, K. F. QUANTITATIVE MORPHOLOGY. Presented at Society of Toxicology, San Deigo, CA, March 05 - 09, 2006.
Description:
Abstract: In toxicology, the role of quantitative assessment of brain morphology can be understood in the context of two types of treatment-related alterations. One type of alteration is specifically associated with treatment and is not observed in control animals. Measurement is not required to detect this type of treatment-related alteration. A second type of alteration is a change in a morphological feature of a structure characteristic of normal animals. Measurement is essential to detect this type of treatment-related alteration. Measurement is essential to assess the dose-dependence of either type of alteration. The objectives of this lecture are to 1) compare ‘model-based’ and ‘designed-based’ approaches to measuring morphological features of brain and 2) compare three different metrics used to quantitatively assess morphological features of magnetic resonance image arrays of the rodent brain. This is an abstract of a proposed presentation and does not necessarily reflect EPA policy.