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CHEMICAL EFFECTS IN BIOLOGICAL SYSTEMS – DATA DICTIONARY (CEBS-DD): A COMPENDIUM OF TERMS FOR THE CAPTURE AND INTEGRATION OF BIOLOGICAL STUDY DESIGN DESCRIPTION, CONVENTIONAL PHENOTYPES AND ‘OMICS’ DATA
Citation:
FOSTEL, J., D. CHOI, C. ZWICKL, N. MORRISON, A. RASHID, A. HASAN, W. BAO, A. RICHARD, W. TONG, P. R. BUSHEL, R BROWN, M. BRUNO, M. L. CUNNINGHAM, D. J. DIX, W. EASTIN, C. FRADE, A. GARCIA, A. HEINLOTH, R. IRWIN, J. MADENSPACHER, B. A. MERRICK, T. PAPOIAN, R. PAULES, P. ROCCA-SERRA, A. S. SANSONE, J. STEVENS, K. TOMER, C. YANG, AND M. WATERS. CHEMICAL EFFECTS IN BIOLOGICAL SYSTEMS – DATA DICTIONARY (CEBS-DD): A COMPENDIUM OF TERMS FOR THE CAPTURE AND INTEGRATION OF BIOLOGICAL STUDY DESIGN DESCRIPTION, CONVENTIONAL PHENOTYPES AND ‘OMICS’ DATA. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 88(2):585-601, (2005).
Impact/Purpose:
To illustrate the utility of the Chemical Effects in Biological Systems Knowledgebase
Description:
A critical component in the design of the Chemical Effects in Biological Systems (CEBS) Knowledgebase is a strategy to capture toxicogenomics study protocols and the toxicity endpoint data (clinical pathology and histopathology). A Study is generally an experiment carried out during a period of time for the purpose of obtaining data, and the Study Design Description captures the methods, timing and organization of the Study. The CEBS Data Dictionary (CEBS-DD) has been designed to define and organize terms in an attempt to standardize nomenclature needed to describe a toxicogenomics Study in a structured yet intuitive format and provide a flexible means to describe a Study as conceptualized by the investigator. The CEBS-DD will organize and annotate information from a variety of sources, thereby facilitating the capture and display toxicogenomics data in biological context by CEBS, i.e. associating molecular events detected in highly-parallel data with the toxicology / pathology phenotype as observed in the individual Study Subjects and linked to the experimental treatments. The CEBS-DD has been developed with a focus on acute toxicity studies, but with a design that will permit it to be extended to other areas of toxicology and biology with the addition of domain-specific terms. To illustrate the utility of the CEBS-DD, we present an example of integrating data from two parallel proteomics and transcriptomics studies of the response to acute acetaminophen toxicity.
