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OUTDOOR AIR POLLUTION AND DNA DAMAGE
Citation:
DEMARINI, D. M. AND L. D. CLAXTON. OUTDOOR AIR POLLUTION AND DNA DAMAGE. OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. BMJ / British Medical Journal Publishing Group, London, Uk, 63(4):227-229, (2006).
Impact/Purpose:
To offer a commentary on the paper by Tovalin et. al. regarding outdoor air exposures
Description:
Although working outdoors has frequently been considered more healthful than working indoors, a growing literature suggests that outdoor air exposures increase the risk for a variety of diseases, such as asthma, heart disease, and lung cancer). Consistent with these epidemiological studies are reports using the 32P-postlabeling assay for stable DNA adducts showing that outdoor air causes DNA damage), which is a prerequisite for most mutation and cancer. Supporting these observations are hundreds of studies using primarily the Salmonella mutagenicity assay demonstrating that the particulate and volatile fractions of outdoor air are mutagenic.