Citation:

GRAHAM, S. E., T. R. MCCURDY, AND K. SHARMA. ALGORITHMS FOR ESTIMATING RESTING METABOLIC RATE AND ACTIVITY SPECIFIC VENTILATION RATES FOR USE IN COMPLEX EXPOSURE AND INTAKE DOSE MODELS. Presented at Society for Risk Analysis 2005 Annual Meeting, Orlando, FL, December 04 - 07, 2005.

Impact/Purpose:

The primary objectives for this task are:

to assess the contribution of outdoor sources to total personal exposures for high priority air toxics and components of particulate matter (PM),

to identify the important microenvironments and human activities contributing to high exposures for these pollutants, and

to evaluate and refine model algorithms and inputs by incorporating new approaches and data, and modularizing model algorithms for application to multiple air pollutants (particles/gases).

Description:

This work summarizes advancements made that allow for better estimation of resting metabolic rate (RMR) and subsequent estimation of ventilation rates (i.e., total ventilation (V_E) and alveolar ventilation (V_A)) for individuals of both genders and all ages. RMR is used in conjunction with activity-specific relative estimates of the energy expended by individuals for each activity that they undertake. These two data are first translated into activity-specific VO₂ estimates and then into V_E and V_A. The RMR equations, along with new V_E and VA algorithms, become the basis for estimating dose rate received associated with exposure to environmental contaminants as simulated individuals go through their daily life. The coordination of these algorithms is critical to maintaining the time-series of exposure and provides a more realistic approach for estimating exposure and absorbed dose than done previously, particularly when considering simultaneous chemical exposure of different pollutant types.

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