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AMBIENT COARSE PARTICLE MATTER ASSOCIATED WITH HRV, BLOOD COAGULATION, AND BLOOD LIPIDS IN ADULT ASTHMATICS
Citation:
YEATTS, K., E. R. SVENDSEN, J. P. CREASON, R. W. WILLIAMS, N. ALEXIS, M. HERBST, L. M. NEAS, R. B. DEVLIN, W. CASCIO, AND D. PEDEN. AMBIENT COARSE PARTICLE MATTER ASSOCIATED WITH HRV, BLOOD COAGULATION, AND BLOOD LIPIDS IN ADULT ASTHMATICS. Presented at American Thoracic Society Annual Meeting, San Diego, CA, May 19 - 24, 2006.
Description:
Introduction: We investigated whether systemic inflammation markers in asthmatics change in response to fluctuations in ambient PM. Methods: Twelve atopic adults with mild to moderate persistent asthma living within a 30 mile radius of the US EPA clinic were followed for twelve weeks. Each subject had nine clinic visits. Blood samples were made on each visit. Daily coarse (PM 10-2.5) and fine (PM 2.5) PM were measured for each 24 hour period using a dichotomous air sampler. Peripheral blood samples were analyzed for markers of blood coagulation, hemostasis, and lipids. Ambulatory HRV was assessed over four consecutive days. Linear mixed models with a spatial covariance matrix function were used to assess potential associations. Results: Heart rate variability as measured by SDNN decreased. PNN50 and high frequency domain (HF) decreased indicating a decrease in vagal autonomic input to the heart associated with coarse PM. With lug/m3 increase in PM 10-2.5, plasminogen decreased 0.01%, fibrinogen decreased 0.05%, triglycerides increased 4.6%, VLDL increased 1.13%. These changes were significant at p<0.05. Conclusions: These data suggest that small temporal increases in ambient levels of PM 10-2.5 are sufficient to affect lipids and blood coagulation factors in the systemic circulation and HRV of adult asthmatics. Elevated lipids may lead to atherosclerotic plaque progression then leading to increased cardiovascular morbidity, an effect currently associated with PM10 exposure. Disclaimer:These findings do not necessarily represent EPA policy.
Funded By: Funding:EPA Cooperative Agreement 829522,NHLBI R01HL62624 Agreement 829522,NHLBI R01HL62624