PROJECT 3 -- INHALATION EXPOSURE ASSESSMENT OF SAN JOAQUIN VALLEY AEROSOL
Impact/Purpose:
Epidemiological evidence suggests that the association between cardiac mortality and PM10 concentrations changes between the summer and winter months in the San Joaquin Valley. This shift is likely caused by seasonal variation in the size and composition distribution of airborne particles. This project will perform inhalation exposure and particle characterization studies at rural and urban locations in the summer and winter months to quantify the features of the airborne particles that are associated with adverse health effects.
Description:
We will identify the composition and size fraction of the airborne particles that cause adverse health effects in the San Joaquin Valley. The source origin of these unhealthy particles will be determined using source apportionment calculations. These findings will support an improved mechanistic understanding of how airborne particles cause negative health effects.
Record Details:
Record Type:PROJECT(
ABSTRACT
)
Start Date:10/01/2005
Completion Date:09/30/2010
Record ID:
144561
Keywords:
CARDIOPULMONARY, ULTRAFINE PARTICLES, HISTOLOGY, IMMUNOHISTOCHEMISTRY, MICROASSAY, BIOLOGY, PATHOLOGY, PHYSICS, ENGINEERING, NANOTECHNOLOGY, METABOLISM, BIOAVAILABILITY, CHEMICAL MASS BALANCE MODEL, AMMONIUM, NITRATES, SULFATES, CARBON, BIOCHEMISTRY, PARTICULATE MATTER, AMBIENT AIR, OZONE, SENSITIVE POPULATIONS, AGRICULTURE, TRANSPORTATION,
Related Organizations:
Role
:OWNER
Organization Name
:UNIVERSITY OF CALIFORNIA - DAVIS
Organization Name
:SJVAHEC
Project Information:
Approach
:Inhalation exposure studies will be carried out using mice that are exposed to ambient airborne particles and concentrated ambient airborne particles in the San Joaquin Valley. Exposures will be conducted in the summer and winter in both an urban and rural location to take advantage of the changes that occur in particle chemical composition and size distribution as a function of season and location. Heart rate variability, lung inflammation, and markers for oxidative stress will be monitored. Collocated measurements of PM2.5 and PM0.1 composition will be made to quantify health effects associated with chemical composition and support source apportionment calculations. Inhalation studies of direct emissions will be conducted for the dominant sources of PM2.5 and PM0.1 that are identified during ambient studies. Based on our results, we will postulate possible mechanisms for health effects and test these using laboratory studies and simple model particles.
Cost
:$.00
Research Component
:Health Effects
Project IDs:
ID Code
:R832414C003
Project type
:Center