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COMMONALITIES IN METABOLISM OF ARSENICALS
Citation:
ADAIR, B., S. B. WATERS, V. DEVESA I PEREZ, Z. DROBNA, M. STYBLO, AND D. J. THOMAS. COMMONALITIES IN METABOLISM OF ARSENICALS. ENVIRONMENTAL CHEMISTRY. CSIRO Publishing, Collingwood Victoria, Australia, 2:161-166, (2005).
Impact/Purpose:
To review evidence for production of methylated metabolism of arsenicals
Description:
Elucidating the pathway of inorganic arsenic metabolism shows that some of methylated arsenicals formed as intermediates and products are reactive and toxic species. Hence, methylated arsenicals likely mediate at least some of the toxic and carcinogenic effects associated with exposure to arsenic. Trimethylarsonium compounds and arsenosugars are two other classes of arsenicals to which humans are routinely exposed and there is evidence that both classes are metabolized to produce methylated arsenicals. Here, we review evidence for production of methylated metabolism and consider the challenges posed in unraveling a complex web for metabolism of arsenicals in humans.