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IRIS Toxicological Review and Summary Documents for 2-Hexanone
Citation:
U.S. EPA. IRIS Toxicological Review and Summary Documents for 2-Hexanone. U.S. Environmental Protection Agency, Washington, DC.
Impact/Purpose:
EPA is undertaking the completion of a health assessment for 2-hexanone to be incorporated into the Integrated Risk Information System (IRIS). The outcome of this project will be a Toxicological Review and an IRIS Summary for 2-hexanone that will be entered into the IRIS database. IRIS is an EPA database containing Agency consensus scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information in support of two steps of the risk assessment process, i.e., hazard identification and dose-response assessment. IRIS provides a nationally and internationally used database of toxicity information that is used in risk assessments, site-specific environmental decisions, and rule making. IRIS assessments are used in combination with specific situational exposure assessment information to evaluate potential public health risks associated with environmental contaminants.
Description:
EPA will conduct an assessment of the noncancer health effects of 2-hexanone. The IRIS program will prepare an IRIS assessment for 2-hexanone. The IRIS assessment for 2-hexanone will consist of a Toxicological Review and an IRIS Summary. The Toxicological Review is a critical review of the physiochemical and toxicokinetic properties of the chemical and its toxicity in humans and experimental systems. The assessment will present reference values for noncancer effects of 2-hexanone (RfD and RfC). The assessment will be subject to internal peer consultation, Agency review, and external scientific peer review. The final products will constitute the Agency's consensus opinion on the toxicity of 2-hexanone.
URLs/Downloads:
Peer Review Plan (PDF, 2 pp, 33 KB, about PDF)Link to Peer Review Charge ERD and Comments 2-Hexanone (PDF, NA pp, 4 KB, about PDF)