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ENVIRONMENTALLY FRIENDLIER SYNTHESES USING MICROWAVES AND ALTERNATIVE REACTION CONDITIONS
Citation:
VARMA, R. S. AND Y. JU. ENVIRONMENTALLY FRIENDLIER SYNTHESES USING MICROWAVES AND ALTERNATIVE REACTION CONDITIONS. Presented at 10th International Conference on Microwave & High Frequency Heating, Modena, ITALY, September 12 - 15, 2005.
Impact/Purpose:
To inform the public.
Description:
A solvent-free approach that involves microwave (MW) exposure of neat reactants (undiluted) catalyzed by the surfaces of less-expensive and recyclable mineral supports such as alumina, silica, clay, or doped surfaces is presented which is applicable to a wide range of cleavage, condensation, cyclization, rearrangement, oxidation and reduction reactions including rapid one-pot assembly of heterocyclic compounds from in situ generated reactive intermediates. A simple, efficient and eco-friendly protocol that involves double N-alkylation of amines is developed and this green chemical reaction proceeds in the presence of aqueous potassium carbonate and the protocol can be extended to a variety of five- and even six-membered heterocyclic systems, e.g. 4,5-dihydropyrazole and pyrazolidine can be synthesized by condensation of hydrazine derivatives with alkyl 1,3-dihalides or -ditosylates.