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MICROWAVE-ASSISTED CYCLOCONDENSATION OF HYDRAZINE DERIVATIVES WITH ALKYL DIHALIDES OR DITOSYLATES IN AQUEOUS MEDIA: SYNTHESES OF PYRAZOLE, PYRAZOLIDINE AND PHTHALAZINE DERIVATIVES
Citation:
JU, Y. AND R. S. VARMA. MICROWAVE-ASSISTED CYCLOCONDENSATION OF HYDRAZINE DERIVATIVES WITH ALKYL DIHALIDES OR DITOSYLATES IN AQUEOUS MEDIA: SYNTHESES OF PYRAZOLE, PYRAZOLIDINE AND PHTHALAZINE DERIVATIVES. B. Ganem, L. Guo-Qiang, E.J. Thomas, J. Wood, Y. Yamamoto, S.Z. Zard (ed.), TETRAHEDRON LETTERS. Elsevier Science Ltd, New York, NY, 46(36):6011-6014, (2005).
Description:
Direct synthesis of 4,5-dihydro-pyrazole, pyrazolidine, and 1,2-dihydro-phthalazine derivatives via double alkylation of hydrazines by alkyl dihalides or ditosylates were accomplished in aqueous media under microwave irradiation conditions; the environmentally friendlier chemical transformation occurred in a single step and eliminated the use of expensive metal catalysts in building two C-N bonds.