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LABORATORY TOXICITY TESTS FOR EVALUATING POTENTIAL EFFECTS OF ENDOCRINE-DISRUPTING COMPOUNDS
Citation:
INGERSOLL, C., T. HUTCHINSON, M. CRANE, S. DODSON, T DEWITT, A. GIES, M. HUET, C. L. MCKENNEY, E. OBERDORSTER, D. PASCOE, D. VERSTEEG, O. WARWICK, AND O. WARWICK. LABORATORY TOXICITY TESTS FOR EVALUATING POTENTIAL EFFECTS OF ENDOCRINE-DISRUPTING COMPOUNDS. In Proceedings, Workshop on Endocrine Disruption in Invertebrates: Endocrinology, Testing and Assessment, Noordwijkerhout, NETHERLANDS, December 12 - 15, 1998. SETAC Techincal Publication, SETAC PRESS, Pensacola, FL, 107-197, (1998).
Impact/Purpose:
Symposium paper
Description:
The scope of the Laboratory Testing Work Group was to evaluate methods for testing aquatic and terrestrial invertebrates in the laboratory. Specifically, discussions focused on the following objectives: 1) assess the extent to which consensus-based standard methods and other published methods for conducting toxicity tests with invertebrates in the laboratory can be used to detect and assess endocrine-disrupting compounds (EDCs); 2) identify the strengths and weaknesses in these methods for use in the ecological risk assessment of EDCs; 3) suggest potential improvements to existing methods and endpoints, and where appropriate, recommend the development of new approaches; and 4) develop a prioritized list of short-term and long-term research needs. During the workshop, 2 additional objectives were identified: 5) evaluate the use of reference compounds to help identify species, life stages, and endpoints potentially responsive to EDCs and to help in the development of standardized tests; and 6) identify groups of organisms that could be evaluated in transgenerational (multigenerational) exposures to detect ecologically relevant effects of EDCs on progeny of exposed organisms