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COMPARISON OF HIGHLY-FLUORINATED CHLOROFORMATES AS DIRECT AQUEOUS SAMPLE DERIVATIZING AGENTS FOR HYDROPHILIC ANALYTES AND DRINKING WATER DISINFECTION BY-PRODUCTS
Citation:
VINCENTI, M., S. BIAZZI, N. GHIGLIONE, M. C. VALSANIA, AND S. D. RICHARDSON. COMPARISON OF HIGHLY-FLUORINATED CHLOROFORMATES AS DIRECT AQUEOUS SAMPLE DERIVATIZING AGENTS FOR HYDROPHILIC ANALYTES AND DRINKING WATER DISINFECTION BY-PRODUCTS. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY. Elsevier Science Ltd, New York, NY, 16(6):803-813, (2005).
Impact/Purpose:
(1) Use a toxicity-based approach to prioritize and identify DBPs that show the greatest toxic response. (2) Comprehensively identify DBPs formed by different disinfectant regimes for the 'Four Lab Study'. (3) Determine the mechanisms of formation for potentially hazardous bromonitromethane DBPs.
Description:
Four highly-fluorinated alkyl and aryl chloroformates, including 2,2,3,3,4,4,5,5-octafluoro-1-pentyl chloroformate (OFPCF), 2,3,4,5,6-pentafluorobenzyl chloroformate (PFBCF), 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-1-octyl chloroformate (TDFOCF) and 2-(2,3,4,5,6-pentafluorophenoxy)-ethyl chloroformate (PFPECF), were synthesized and tested as reagents for the direct water derivatization of polar and hydrophilic analytes. The goal of this research was to develop an optimal derivatizing agent to aid in the identification of highly polar ozonation drinking water disinfection by-products (DBPs) that are believed to be missed with current analytical procedures.