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DOSE-RESPONSE MODELING FOR EPAS ORGANOPHOSPHATE CUMULATIVE RISK ASSESSMENT: COMBINING INFORMATION FROM SEVERAL DATASETS TO ESTIMATE RELATIVE POTENCY FACTORS
Citation:
SETZER, R. W. DOSE-RESPONSE MODELING FOR EPAS ORGANOPHOSPHATE CUMULATIVE RISK ASSESSMENT: COMBINING INFORMATION FROM SEVERAL DATASETS TO ESTIMATE RELATIVE POTENCY FACTORS. Presented at Society of Toxicology Assessment Specialty Section Teleconference, Raleigh, NC, June 08, 2005.
Impact/Purpose:
The US EPA’s Organophosphate Cumulative Risk Assessment (OPCRA) considers the effects of exposure to 33 organophosphorous pesticides (OPs) through the diet, water, and residential exposures. The OPCRA combines a relative potency factor (RPF) approach to dose-response assessment with a probabilistic exposure assessment to estimate distributions of margins of exposure in the US population. This presentation will deal with the calculation of RPFs for the oral route of exposure, as this route had by far the richest dataset.richest dataset.
Description:
This presentation will deal with the calculation of Relative Potency Factors (RPFs) for the oral route of exposure, as this route had by far the richest dataset.richest dataset.