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MEETING AT BALTIMORE, MD: DISTRIBUTION OF CHIRAL PCBS IN SELECTED TISSUES IN THE LABORATORY RAT
Citation:
LEHMLER, H. J., I. KANIA-KORWEL, J. K. AVANTS, K. C. HORNBUCKLE, L. W. ROBERTSON, W. W. SULKOWSKI, AND A. W. GARRISON. MEETING AT BALTIMORE, MD: DISTRIBUTION OF CHIRAL PCBS IN SELECTED TISSUES IN THE LABORATORY RAT. Presented at Society of Environmental Toxicology and Chemistry Annual Meeting, Baltimore, MD, November 13 - 17, 2005.
Impact/Purpose:
To determine the environmental occurrences, fate, and effects of the enantiomers of selected chiral pesticides and other chiral pollutants.
Description:
In order to investigate the tissue distribution and enantiomeric fractions (EFs) of Polychlorinated Biphenyl (PCB) atropisomers, immature male Sprague-Dawley rats were administered environmentally relevant doses of (a) Aroclor 1254 or (b) an environmental mixture extracted from soil contaminated with Chlorofen, a Polish PCB mixture. The differences in the induction of PCB metabolizing enzymes may be responsible for the differences in the enantiomeric enrichment between both groups.