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MOMENTARY BRAIN CONCENTRATION OF TRICHLOROETHYLENE PREDICTS THE EFFECTS ON RAT VISUAL FUNCTION.
Citation:
BOYES, W. K., M. S. BERCEGEAY, TODD T. KRANTZ, M. V. EVANS, V. A. BENIGNUS, AND J. E. SIMMONS. MOMENTARY BRAIN CONCENTRATION OF TRICHLOROETHYLENE PREDICTS THE EFFECTS ON RAT VISUAL FUNCTION. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 87(1):187-196, (2005).
Description:
This manuscript demonstrates that the level neurological impairment following acute reversible exposure to trichloroethylene, a volatile organic compound, is more accurately described when extrapolations across exposure conditions are based on target tissue (brain) dose level, than when using other standard risk assessment approaches. In addition, this manuscript describes a quantitative relationship between the brain concentration of trichloroethylene and neurophysiological decrements both during and after termination of exposure. Existing risk assessment methods do not allow clear predictions of the level of impairment after termination of exposure while residual compound remains present in the tissues. Thus, the data and quantitative model described in this manuscript enable risk assessments to be both more accurate and applicable to more situations than current risk assessment procedures.