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The study was conducted jointly between CDC and Chinese health officials in 1998 to determine folic acid's effectiveness in reducing rates of neural tube defects (NTDs) in two areas of China. In summary, this study showed that in northern China, which has a high incidence of NTDs, women who took 400 micrograms (0.4mg) of folic acid daily at least 80% of the time before and in the early stages of pregnancy reduced their risk of having an NTD-affected pregnancy by 85%. Among participating women in southern China, where the incidence was lower (similar to the U.S. NTD rate), the reduction in risk was 40%.

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