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TOXICITY-BASED IDENTIFICATION OF DRINKING WATER DISINFECTION BY-PRODUCTS USING LC/MS AND LC/MS/MS
Citation:
RICHARDSON, S. D., F. G. CRUMLEY, J. CHOI, M. J. PLEWA, AND E. WAGNER. TOXICITY-BASED IDENTIFICATION OF DRINKING WATER DISINFECTION BY-PRODUCTS USING LC/MS AND LC/MS/MS. Presented at First International Workshop on Liquid Chromatography-Tandem Mass Spectrometry for Screening and Trace Level Quantitation in Environmental and Food Samples, Barcelona, SPAIN, June 20 - 21, 2005.
Impact/Purpose:
(1) Use a toxicity-based approach to prioritize and identify DBPs that show the greatest toxic response. (2) Comprehensively identify DBPs formed by different disinfectant regimes for the 'Four Lab Study'. (3) Determine the mechanisms of formation for potentially hazardous bromonitromethane DBPs.
Description:
The goal of this research is to use a bio-assay directed approach to focus identification work on the most toxicologically important disinfection by-products. To this end, drinking water is being collected from full-scale treatment plants that use chlorine, ozone, chlorine dioxide, and chloramines as disinfectants, and this drinking water is being fractionated according to polarity (through the use of different polarity XAD resins, preparatory liquid chromatography columns, and solvent gradients) and molecular size (through the use of ultrafiltration and size exclusion chromatography).