Citation:

LINDSTROM, A. B. RECENT DEVELOPMENTS IN EXHALED BREATH ANALYSIS AND HUMAN EXPOSURE ASSESSMENT RESEARCH. Presented at Breath Analysis for Medical Diagnosis and Therapeutic Monitoring, Innsbruck, AUSTRIA, May 26 - 28, 2005.

Impact/Purpose:

The objective of this task is to develop state-of-the-art methods for measuring xenobiotic compounds, to include the isolation of the analyte from the appropriate matrix (extraction), preconcentration (typically sorbent-based), and analysis via GC/MS and/or LC/MS. Once established, these methods will be applied in small scale pilot studies or demonstration projects. Particular emphasis will be placed on methods which are readily transferable to other laboratories, including those within the Human Exposure and Atmospheric Sciences Division (HEASD), the National Exposure Research Laboratory (NERL), other EPA Laboratories, Program Offices, Regions, and academic institutions.

Specific objectives of this task include the following:

1) Development of GC/MS and LC/MS methods for the measurement of key xenobiotic compounds and their metabolites (to include the pyrethroid pesticides, perfluorinated organic compounds, and the BFRs) in relevant environmental and biological matrices.

2) Development of efficient low cost methods for the extraction and clean up of these compounds collected from relevant matrices.

3) Determination of xenobiotic compound and metabolite concentrations in samples derived from laboratory and field monitoring studies to help assess exposures and evaluate associated risks.

Description:

This presentation will explore historical and newly emerging methods for the collection and analysis of exhaled breath for use in environmental exposure assessment studies. We will discuss their applicability and limitations with respect to environmental research. Particular emphasis will be placed on new methods and their utility for examining exhaled biomarkers of environmental pollution.

Record Details: