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DOSE RESPONSE OF CRYPTOSPORIDIUM PARVUM IN OUTBRED NEONATAL CD-1 MICE
Citation:
Finch, G. R., C. W. Daniels, E. K. Black, F W. Schaefer, AND M. Belosevic. DOSE RESPONSE OF CRYPTOSPORIDIUM PARVUM IN OUTBRED NEONATAL CD-1 MICE. L.N.Ornston (ed.), APPLIED AND ENVIRONMENTAL MICROBIOLOGY. ASM Press, Washington, DC, 59(11):3661-3665, (1993).
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Description:
Cryptosporidium parvum infectivity in a neonatal CD-1 mouse model was used to determine the dose needed to infect 50% of the population. The 50% infective dose was estimated to be 79 oocysts. It was observed that a mean oral inoculum of 23 oocysts produced infection in 2 of 25 neonatal mice 7 days postinoculation. All animals became infected when the mean oral dose exceeded 310 oocysts per animal. The dose response of C. parvum was modeled with a logit dose-response model suitable for use in water disinfection studies.
