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In vitro-in vivo Quantitative Extrapolation of Hepatic Metabolism Data for Fish: A Review of Methods and Strategies for Incorporating Intrinsic Clearance Estimates into Chemical Kinetic Models
Citation:
NICHOLS, J. W., I. R. SCHULTZ, AND P. N. FITZSIMMONS. In vitro-in vivo Quantitative Extrapolation of Hepatic Metabolism Data for Fish: A Review of Methods and Strategies for Incorporating Intrinsic Clearance Estimates into Chemical Kinetic Models. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 78(2006):74-90, (2006).
Impact/Purpose:
to review methods to perform in vitro-in vivo metabolism extrapolations and discuss how these methods could be adapted for use with fish.
Description:
The approaches described in this paper will substantially improve risk assessments for compounds that undergo biotransformation. The purpose of this report is to review methods used by mammalian researchers to perform in vitro-in vivo metabolism extrapolations, discuss how these methods could be adapted for use with fish, and describe how extrapolated values could be incorporated into compartmental kinetic models for fish.