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ALTERED CRANIOFACIAL GENE EXPRESSION OF NEURULATION STAGED MOUSE EMBRYO CULTURES EXPOSED TO BROMOCHLOROACETIC ACID
Citation:
KAROLY, E., J. E. SCHMID, M. R. BLANTON, AND E. S. HUNTER. ALTERED CRANIOFACIAL GENE EXPRESSION OF NEURULATION STAGED MOUSE EMBRYO CULTURES EXPOSED TO BROMOCHLOROACETIC ACID. Presented at Gordon Research Conference on Toxicogenomics, New London, NH, June 05 - 10, 2005.
Description:
An unintended consequence of chemical disinfection of municipal drinking water is the production of chemical disinfection by-products (DBPs). A major class ofDBPs are haloacetic acidsthat may be found at concentrations higher than other DBPs. Bromochloroacetic acid (BCA) is a developmental toxicant in animal models. In order to examine the mechanism of BCA induced dysmorphogenesis at the molecular level, CD-1 mouse embryos (3 to 6 somite stage) were cultured in 300
This is an abstract of a proposed presentation and does not necessarily reflect EPA policy. Funded by EPA/UNC Toxicology research program, training agreement CT 827206 with the Curriculum of Toxicology, University of North Carolina at Chapel Hill, North Carolina.